Objective: To conduct a systematic review of the efficacy and safety of the Fire Dragon Cup Comprehensive Moxibustion Therapy for peripheral facial paralysis. Methods: Clinical studies on the use of Fire Dragon Cup therapy for patients with peripheral facial paralysis were retrieved from eight databases, including PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Database, with the search period ranging from the establishment of the databases to August 2025. Two researchers evaluated the quality of randomized controlled trials using Cochrane 5.1.0 based on inclusion and exclusion criteria. Meta-analysis was performed using RevMan 5.4 software to analyze and integrate the literature. Results: There was no statistically significant difference in the incidence of adverse events between the two groups (RD = -0.00, P = 0.85), with adverse events primarily consisting of minor reactions such as subcutaneous bleeding and dry mouth, and no severe adverse events were reported. The Fire Dragon Cup Comprehensive Moxibustion Combined Therapy significantly outperformed the control group in improving facial nerve function indicators (P < 0.05). None of the included studies implemented allocation concealment or blinding, and most were single-center, small-sample trials conducted in Chinese. Conclusion: Fire Dragon Cup Comprehensive Moxibustion Therapy is safe and effective for treating peripheral facial paralysis, providing evidence-based support for clinical treatment. However, further validation through higher-quality, multi-center studies is required.