【】Objective To explore the mechanism of action of "Bupleurum-Scutellaria baicalensis" on acute pancreatitis based on network pharmacology and molecular docking technology. Method The traditional Chinese medicine systems pharmacology database and analysis platform were used to screen out the active ingredients of Bupleurum and Scutellaria baicalensis, and the compounds were further screened with the help of the SwissADME platform. Use the SwissTarget Prediction database to predict potential targets of ingredients, Apply Disgnet database, Gene Cards database, and OMIM database to obtain targets related to acute pancreatitis, Intersect the targets related to the active chemical components of Bupleurum and Scutellaria baicalensis with the targets related to acute pancreatitis, and draw a Venn diagram; Aiming at the intersection of the two targets, the STRING 12.0 database and Cytoscape3.9.1 software were used to construct a protein-protein interaction (PPI) network; Metascape database was used to conduct Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on key drug and disease targets. The "TCM-active ingredients-targets-disease-pathway" network diagram is constructed through Cytoscape3.9.1. Finally, software such as AutoDockTools1.5.7 was used for molecular docking verification, and Pymol was used for molecular docking visualization. Result A total of 41 effective chemical components, a total of 488 action targets, and 1,639 disease-related targets were screened out in "Bupleurum-Scutellaria baicalensis". There is an intersection relationship between the 180 targets of the drug and acute pancreatitis. The core targets are ABCB1, SIRT1, MMP2, CCND1, NR3C1, etc. The GO analysis results mainly involve biological processes such as the regulation of phosphorylation, phosphate metabolism, cell migration and movement, etc. KEGG is mainly enriched in cancer pathways, PI3K-Akt signaling pathway, Rap1 signaling pathway, apoptosis, TNF signaling pathway, etc. Five active ingredients in Bupleurum and Scutellaria baicalensis“Norwogonin、baicalein、isorhamnetin、5,7,4"-Trihydroxy-8-methoxyflavone、quercetin ” ,It can effectively combine with ABCB1, SIRT1, MMP2, CCND1, and NR3C1. In Conclusion “Bupleurum-Scutellaria baicalensis” can treat acute pancreatitis through multi-component, multi-dimensional, multi-dimensional, and multi-channel. The ingredients that play an important role are “Norwogonin、baicalein、isorhamnetin、5,7,4"-Trihydroxy-8-methoxyflavone、quercetin ”,The target is ABCB1, SIRT1, MMP2, CCND1, NR3C1, It plays a comprehensive role in anti-inflammatory response, anti-apoptosis, and anti-oxidative stress response. Provide theoretical basis and reference basis for subsequent research.