MUC5AC在重症肺炎痰热壅肺证患者气道中的表达及临床意义
作者:
作者单位:

福建中医药大学附属第三人民医院(福建 福州 321400)

作者简介:

刘宏波,男,主治医师。研究方向:中医药防治呼吸系统疾病。E-mail:1923212882@QQ.COM

基金项目:

※基金项目 福建中医药大学校管临床专项资助项目(No.XB2022042)

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    摘要:

    目的 探究重症肺炎痰热壅肺证患者气道内黏蛋白5AC(MUC5AC)的表达状况,并对MUC5AC与急性生理与慢性健康评分Ⅱ(APACHEⅡ)、临床肺部感染评分(CPIS)、序贯器官衰竭评估(SOFA)、感染相关指标以及中医证候评分之间的相互关系进行深入分析,旨在评估MUC5AC对于诊断该病症的意义。方法 本次研究选取了64位重症肺炎患者作为试验对象,根据中医辨证分型标准将研究对象分为重症肺炎痰热壅肺组(n=32)、风热犯肺组(n=32),另选取支气管异物患者作为对照组(n=16)。收集各组临床资料、评分量表及实验室检查数据。结果 与对照组相比,痰热壅肺组MUC5AC、APACHEⅡ、SOFA评分、CPIS评分、感染指标、中医证候评分均升高,差异具有统计学意义(P<0.01);与风热犯肺组相比,痰热壅肺组MUC5AC、APACHEⅡ、SOFA评分、CPIS评分、白细胞、中医证候评分均升高,差异具有统计学意义(P<0.05),而在CRP、PCT两项感染指标上,两组间比较无统计学差异(P>0.05);MUC5AC与痰热壅肺组中医证候评分、APACHEⅡ、SOFA评分、CPIS评分、感染指标均呈正相关((r>0.5,P<0.01);ROC曲线显示,中医证候评分、APACHEⅡ、SOFA评分、CPIS评分四项联合对重症肺炎痰热壅肺证的诊断价值高于中医临床证候评分单项诊断(AUC=0.988,P<0.05);以MUC5AC水平绘制受试者工作特征曲线,当cutoff值为1.531时,其曲线下面积为0.953,预测痰热壅肺发生的灵敏度为93.8%,特异度为87.5%。结论 重症肺炎痰热壅肺证患者气道内存在MUC5AC高表达,MUC5AC对重症肺炎痰热壅肺证病情严重性具有一定预测性,可作为判断重症肺炎痰热壅肺证的辅助依据。

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刘宏波,王庆,安志鹏,吴冬妹,李小清,郑雪婷,魏旭威. MUC5AC在重症肺炎痰热壅肺证患者气道中的表达及临床意义[J].,2024,23(10):42-47

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  • 收稿日期:2024-04-18
  • 最后修改日期:2024-04-18
  • 录用日期:2024-08-19
  • 在线发布日期: 2025-01-02