基于“培土生金”理论探究加味六君子汤对肺脾气虚型慢性阻塞性肺疾病的临床疗效
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江西省景德镇市中医医院(江西 景德镇 333000)

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创新研究群体科学基金


Based on the theory of "cultivating soil and generating gold", the clinical efficacy of modified Liujunzi Decoction in the treatment of copd was investigated
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    摘要:

    目的 基于“培土生金”理论探究加味六君子汤对慢性阻塞性肺疾病(COPD)的临床疗效。方法 收集90例肺脾气虚型COPD患者,随机分为对照组、观察组各45例。比较两组临床疗效及干预前后呼吸功能指标、免疫指标、营养指标及炎症指标的变化。结果 治疗后,对照组、观察组有效率分别为86.05%、95.46%,两组FEV1%、FEV1/FVC、FEF 25%、FEF 50%水平与治疗前比较均有所提升(P<0.05),TNF-α、IL-6、IL-33水平与治疗前比较均有所下降(P<0.05),且观察组上述指标的改善程度明显优于对照组(P<0.05)。治疗后,观察组在IgG、IgA、IgM、体重、白蛋白、转铁蛋白等指标方面与治疗前比较,差异有统计学差异(P<0.05),对照组治疗前后比较无统计学差异(P>0.05)。结论 加味六君子汤治疗COPD临床疗效显著,其主要是通过改善营养状况,提升机体免疫力,进而降低炎症水平,缓解炎症反应,改善小气道呼吸功能,从而改善COPD患者的生活质量。

    Abstract:

    Objective: Based on the theory of "cultivating soil and generating gold", the clinical efficacy of Liujunzi Decoction in treating copd at different weeks was investigated. Methods: A total of 90 patients with COPD with Lung-spleen qi deficiency treated in Jingdezhen Traditional Chinese Medicine Hospital from January 2020 to January 2022 were randomly divided into western medicine group, Chinese medicine group A and Chinese medicine group B, with 30 cases in each group.?The clinical efficacy, respiratory function index, immune index,Nutrition indicators and inflammatory index levels of the three groups were compared before and after intervention. Results: After treatment, the effective rates of western medicine group, Chinese medicine A group and Chinese medicine B group were 78.57%, 86.21% and 96.67%, respectively, and the levels of [ 第一作者:黄明儒,医学硕士,中医师,2581912372@qq.com 电话:18720928851 通讯作者:江久,医学学士,副主任中医师,917869664@qq.com 电话:18979866518 课题基金:江西省卫生健康委(2018A186) ]FEV1%,FEV1/FVC,FEF25% and FEF50% were improved (P<0.05), the levels of TNF-α,IL-6 and IL-33 were decreased (P<0.05); The above indexes in Chinese medicine group (group A, group B) were significantly higher than those in Western medicine group (P<0.05), and group B was more significant than group A (P<0.05). There were no significant differences in IgG, IgA IgM, Body weight, albumin and transferrin before and after treatment in western medicine group (P>0.05). After treatment, the levels of IgG, IgA, IgM ,Body weight, albumin and transferrin in Chinese medicine?group (group A and B) were statistically different, and group B was more significant than group A (P<0.05). Conclusion: Modified Liujunzi Decoction has significant clinical efficacy in the treatment of COPD, which mainly improves the quality of life of COPD patients by improving the body's immunity, thereby reducing the level of inflammation, alleviating the inflammatory response, improving the respiratory function of small airway, and the longer the week, the more significant the efficacy.

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黄明儒,黄钬清,冯林香,向琴,张一鸣,王静,洪敏,刘亚茹,江久.基于“培土生金”理论探究加味六君子汤对肺脾气虚型慢性阻塞性肺疾病的临床疗效[J].,2023,22(9):43-46

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  • 收稿日期:2022-04-19
  • 最后修改日期:2022-05-06
  • 录用日期:2022-05-20
  • 在线发布日期: 2023-12-07
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