基于网络作用探讨苍耳子的毒性作用机制*
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1.河南中医药大学 河南郑州;2.河南省中医院 河南郑州

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Toxicity mechanism of Xanthii Fructus based on network effect
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    摘要:

    目的 使用网络毒理学的方法预测苍耳子主要毒性化学成分的毒性作用机制。方法 使用中国系统药理数据库与分析平台(TCMSP),比较毒物基因组学数据库(CTD)得到7种苍耳子的有毒活性成分。并使用SwissTargetPrediction数据库查询苍耳子有毒活性成分的作用靶点。并使用cytoscape软件对苍耳子的7种毒性成分、作用靶点蛋白进行互作网络构建。使用生物学信息注释数据库(DAVID)进行基因本体生物过程功能富集分析与京都基因和基因组百科全书通路富集分析,得到苍耳子的有毒活性成分可能通过那些通路对机体产生危害作用。结果 苍耳子的有毒活性成分联系度最高的蛋白PTPN1、BCHE、CHRM2等以及苍耳子的有毒活性成分可能通过氮素代谢通路、雌激素信号通路、钙离子信号通路、TNF信号通路、cAMP信号通路等产生肝肾毒性,对神经系统、呼吸系统、循环系统的功能产生危害作用。结论 探讨了苍耳子的毒性作用机制,并预测了苍耳子可能存在的毒性,并为分析中药有毒化学成分以及探讨中药毒性作用机制提供了一个角度。

    Abstract:

    Purpose to predict the toxic mechanism of the main toxic chemical components in Xanthii Fructus by network toxicology. Methods the toxic active components of 7 kinds of Xanthium Fructus were obtained by comparative toxicology genomics database (CTD) and Chinese systematic pharmacology database and analysis platform (tcmsp). Swisstargetprediction database was used to query the target of toxic active components in Xanthium Fructus. The interaction network of seven toxic components and target proteins of Xanthium Fructus was constructed by using Cytoscape software. The biological information annotation database (David) was used to analyze the functional enrichment of biological processes of genes and Kyoto Encyclopedia of genes and genomes. It was found that the toxic active components of Xanthium Fructus might cause harm to the body through those pathways. Results the proteins PTPN1, BChE, CHRM2 and so on with the highest degree of contact with the toxic active components of Xanthii Fructus, as well as the toxic active components of Xanthii Fructus, may produce hepatorenal toxicity through nitrogen metabolism pathway, estrogen signaling pathway, calcium ion signaling pathway, TNF signaling pathway, cAMP signaling pathway, and have harmful effects on the functions of nervous system, respiratory system and circulatory system. Conclusion the toxic mechanism of Xanthii Fructus was discussed, and the possible toxicity of Xanthii Fructus was predicted, which provided an angle for analyzing toxic chemical components of traditional Chinese medicine and exploring the toxic mechanism of traditional Chinese medicine.

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  • 收稿日期:2021-05-31
  • 最后修改日期:2021-07-25
  • 录用日期:2021-09-22
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