参芪地黄汤联合缬沙坦治疗气阴两虚型早期糖尿病肾病31例临床观察
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1.福建中医药大学附属第二人民医院;2.福建中医药大学

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Clinical observation on 31 cases of early diabetic nephropathy with defificiency of both qi and yin treated with modified Shenqi Dihuang decoction combined with Valsartan capsule
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    摘要:

    目的:研究参芪地黄汤联合缬沙坦胶囊对气阴两虚型早期糖尿病肾病的疗效、炎症因子及血液流变学的影响。方法:按随机数字表法将2018.1-2020.1本院接诊的62名糖尿病肾病患者分为对照组和观察组各31名。对照组给予糖尿病常规降糖治疗(包括口服药及胰岛素)及缬沙坦胶囊降蛋白治疗;观察组在对照组降糖、降蛋白的基础上加用参芪地黄汤治疗。评估两组观察对象的临床疗效及不良反应。结果:观察组总有效率(93.55%)优于对照组总有效率(74.19%)(P<0.05);观察组治疗后中医症候积分明显低于治疗前,且对比对照组明显具有优势(P<0.05);2组患者治疗后空腹血糖(FPG)、糖化血红蛋白(HbAlc)、尿白蛋白/肌酐比值(uACR)较治疗前降低,观察组治疗后FPG、HbA1c、uACR明显低于对照组(P<0.05);2组患者治疗后C-反应蛋白(CRP)、肿瘤坏死因子-a(TNF-a)、白细胞介素-6(IL-6)、全血高切粘度(HBV)、低切粘度(LBV)、血浆粘度(PV)水平较治疗前降低,观察组治疗后CRP、TNF-a、IL-6、HBV、LBV、PV水平降低程度对比对照组明显具有优势(P<0.05)。结论:使用参芪地黄汤联合缬沙坦胶囊能显著缓解气阴两虚型早期糖尿病肾病的临床症状、炎症反应、血流动力学障碍,同时改善患者血糖、进一步降低尿微量白蛋白,收到更好的临床疗效,值得在临床治疗中大力推荐。

    Abstract:

    Objective To explore the effects of Shenqi Dihuang decoction combined with Valsartan capsule on clinical effection,inflammatory factors and hemorheology in patients with early diabetic nephropathy with defificiency of both qi and yin.Methods A total of 62 patients with diabetic nephropathy from January 2018 to January 2020 were randomly assigned to a control group and a treatment group.The control group was given routine treatment of diabetes and Valsartan capsule;the treatment group was treated with Shenqi Dihuang decoction.The symptoms, laboratory parameters and adverse reactions were observed.Results The total effective rate of the treatment group (93.55%) was better than that of the control group (74.19%)(P<0.05).The TCM Symptom score of the treatment group was significantly lower than that of the control group after treatment(P<0.05).FPG,HbA1c and uACR were lower in 2 groups after treatment than before treatment;FPG,HbA1c and uACR in the treatment group were significantly lower than those in the control group (P<0.05).After treatment, CRP,TNF-a,IL-6,HBV,LBV and PV in 2 groups were lower than that before treatment;CRP,TNF-a,IL-6,HBV,LBV and PV in the treatment group were significantly lower than those in the control group (P<0.05).Conclusion The combination of Shenqi Dihuang decoction and Valsartan capsule can significantly improve the clinical symptoms inflammatory and hemodynamics of early diabetic nephropathy with defificiency of both qi and yin,at the same time, the patient's blood sugar was improved, and the Microalbuminuria was further reduced.

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  • 收稿日期:2021-02-26
  • 最后修改日期:2021-07-26
  • 录用日期:2021-09-02
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