Abstract:Objective:To systematically evaluate the efficacy and safety of Wandai Decoction with western medicine in the treatment for recurrent vulvovaginal candidiasis(RVVC). Methods:CNKI, Sinomed, WanFang, VIP, PubMed, Cochrane Library, and EMbase were searched from the database establishment to December 2019 to collect the randomized controlled trials(RCT) about the treatment of RVVC with Wandai Decoction combined with western medicine, and the data were analyzed by RevMan 5.3 software. Results:10 studies were included and the total sample size was 1075 cases. Meta analysis results demonstrated that in the total clinical effective rate,Wandai Decoction with western medicine was superior to western medicine. In addition, Wandai Decoction with western medicine was better than western medicine in terms of reducing recurrence rate and improving vaginal microecology. Conclusion:Wandai Decoction with western medicine has superior efficacy in the treatment for RVVC, and this conclusion still needs to adopt well-designed large-sample RCT to verify its reliability.