Through the analysis of the etiology and pathogenesis of ankylosing spondylitis, it is believed that the key to the pathogenesis of the disease is yang deficiency of the spleen and kidney, and cold-dampness blockage. The Yang deficiency of the Du Channel and the stasis of the collaterals are the meridian basis of the pathogenesis of ankylosing spondylitis. Insufficiency of Du Yang and malfunction of brain and nerves are important mechanisms for the occurrence of symptoms such as pain and joint damage. Therefore, during clinical treatment, the etiology and pathogenesis of the disease should be focused on warming the yang, warming the spleen and kidney, dispelling cold and removing dampness; in addition, for the pain symptoms, it is emphasized to warm the yang qi, refresh the mind and nourish the mind, so as to promote the operation of the brain and the nerves, and then play a soothing and analgesic. Reduce damage to skin, muscles, veins and joints and joint deformation. Therefore, paying attention to the application of Wenyang Tongdu and Anshen Analgesia in the treatment of ankylosing spondylitis will help improve the clinical efficacy.