Abstract:The novel coronavirus pneumonia (COVID-19) is a new acute infectious pneumonia outbreak at the end of 2019.It is characterized by high infectivity and great harmfulness, and belongs to the category of "epidemic diseases" in traditional Chinese medicine. At present, the epidemic has been widely involved in many countries, and has become a major health problem that cannot be ignored in the world. China"s traditional medicine has rich experience in anti-epidemic prevention. Theory of epidemic caused by "Sanxu" has proposed three major conditions for the occurrence of the epidemic disease. Based on the theory of epidemic caused by "Sanxu", the paper discusses the pathogenesis of the new coronavirus pneumonia, and puts forward the following points: emphasizing the transportation of Qi, regulating the Yin and Yang of the viscera, avoiding the poisonous gas, and treatment in accordance with three categories of etiologic factors, making it appropriate to fight against "Sanxu" to prevent and cure the epidemic disease.